Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.
Bioorganic & Medicinal Chemistry Letters（2006）
摘要
The design, synthesis, and biological evaluation of potent isothiazole inhibitors of the TrkA kinase is presented.
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关键词
TrkA,Antagonist,Isothiazole,Homology model,Synthesis
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