The impact of V30A mutation on transthyretin protein structural stability and cytotoxicity against neuroblastoma cells.

•V30A mutation impaired the thermodynamic and kinetic stabilities of TTR protein.•The V30A variant induced apoptosis and autophagy in the IMR-32 cell line.•The V30A variant induced ROS generation and DNA double-strand breaks.•The instability of V30A variant may be the source of pathology for this FAP family.