PH-sensitive Laponite?/doxorubicin/alginate nanohybrids with improved anticancer efficacy

Mara Gon?alves,Priscilla Figueira,Dina Maciel,Jo?o Rodrigues,Xue Qu,Changsheng Liu,Helena Tom��s,Yulin Li

Acta Biomaterialia（2014）

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摘要

Doxorubicin-loaded Laponite®/alginate (LP/Dox/AG) nanohybrids are endocytosed by CAL-72 cells and intracellularly release doxorubicin with a high efficiency. The presence of Laponite® overcomes drug resistance probably by circumventing Dox-trapping in endo-lysosomal vesicles.

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关键词

Laponite®,Doxorubicin,Alginate,pH-sensitive nanohybrids,Drug delivery

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