Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography–electrospray ionization-tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis（2014）
摘要
•A LC–MS/MS method was developed for determination of seven compounds in rat plasma.•The validated method was successfully applied to a pharmacokinetic study of GGD.•It might provide a basis for clarifying the active compounds of GGD in treating PD.
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关键词
Ge-Gen Decoction,Isoflavones,Monoterpene glucosides,LC–ESI-MS/MS,Pharmacokinetics
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