Pharmacokinetics of ungeremine acetate in rats

AIM: To investigate the pharmacokinetic of ungeremine acetate (AT1840) in rats. METHODS: At1840 was detected by fluorescence method. RESULTS: It was found that the characteristics of the plasm drug concentration time curve fit the two compartment model after iv injection of this drug to rats. The half life time was 0.57 min for distribution phase and 5.51 min for elimination phase. Drug accumulation was highest in lung, kidney, second in liver, ovary, heart, spleen, stomach, and lowest in muscle, fat and brain. AT1840 excreted in urine, bile and faces within 24 h was 23.28%, 36.46% and 1.79% of the total dose administered, respectively. The binding percentage of AT1840 to plasm protein was 68.5%~73.9%. CONCLUSION: AT1840 had short half-life time and distributed in tissues selectively.