[Significance for the detection of human papillomavirus DNA in cervical atypical glandular cells].

OBJECTIVE:To evaluate the potential link between high-risk human papilloma virus (HPV)DNA testing and histological diagnosis in women referred for atypical glandular cells (AGC) at Pap smear. METHODS:All cervical cytological examinations with the diagnosis of AGC between January 2007 and Dec 2009 were identified by means of a computerized database in 97 patients. The histopathological results of cervix were analyzed by colposcopic biopsy, dilatation and curettage (D&C), cervical loop electrosurgical excision procedure (LEEP) and high-risk human papilloma virus DNA testing. RESULTS:(1) All patient were monitored by colposcopy, histopathology and HPV DNA test. Sixty-four patients had pathologic lesions. (2) In predicting the presence of high-grade of cervical intraepithelial neoplasia, the sensitivity of human papilloma virus was 96%, specificity 92.86%, positive predictive value 96% and negative predictive value 92.86%. (3) 98.9% of the AGC patients received colposcopic, cytological examinations and HPV test at follow-ups: 3 cases of PAP smear and 6 cases of HPV testing were abnormal at the first follow-up, and 100% negative for cytological examination and HPV test at the second follow-up visit. CONCLUSION:HPV DNA test and colposcopic examination are effective in the initial evaluation and subsequent follow-ups of cytological atypical glandular cells.