Relationship between 24-hour mean pulse pressure and the cardiac function in the elderly with isolated systolic hypertension

Objective: To investigate the effect of mean pulse pressure during 24 hours on cardiac function in the elderly with isolated systolic hypertension. Methodology: One hundred seventy two elderly patients with isolated systolic hypertension were enrolled to determine mean pulse pressure by monitoring 24-hour ambulatory blood pressure and to analyze the cardiac function by nuclide cardiac blood pool imaging. Results: Twenty four hours mean pulse pressure negatively correlated with left ventricular ejection fraction (LVEF) (r = -0.46, P < 0.01), and also with peak filling rate (RFR) (r = -0.41, P < 0.05). The greater the mean pulse pressure, the worse the cardiac function (P < 0.01). Conclusion: The 24-hours mean pulse pressure was an important factor predicting risk for cardiac disfunction in the elderly with isolated systolic hypertension.