Effects of Glycyrrhiza Extract on Pharmacokinetics Property of Daphnetin in Rats

OBJECTIVE:To research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs.METHOD:The rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2.1.1.RESULT:Glycyrrhiza extract can reduce the t(1/2), tmax and Ke of daphnetin, while increased the Ka and AUC(0-infinity).CONCLUSION:Glycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.