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Sirna-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Rob S. Burke,Inthirai Somasuntharam,Paul Rearden,Duncan Brown,Sujal V. Deshmukh, Martha A. DiPietro,Jillian DiMuzio,Roy Eisenhandler,Scott E. Fauty,Christopher Gibson,Marian E. Gindy, Kelly A. Hamilton,Ian Knemeyer,Kenneth A. Koeplinger, Hae Won Kwon,Traci Q. Lifsted,Karsten Menzel,Mihir Patel,Nicole Pudvah,Deanne Jackson Rudd,Jessica Seitzer,Walter R. Strapps,Thomayant Prueksaritanont,Charles D. Thompson,Jerome H. Hochman,Brian A. Carr

Pharmaceutical research（2014）

引用 4|浏览33
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摘要
To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo, with the aim of improving plasma exposure of these drugs.
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关键词
P450 oxidoreductase,siRNA,drug metabolism,pharmacokinetics
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