Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies.

Current Opinion in Virology（2014）

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摘要

•RNA-dependent RNA polymerases (RdRps) are important anti-viral targets.•Internal motions are coordinated and conserved in RdRps.•Interfering with these motions disrupts RdRp and virus function.•RdRp variants with altered dynamics serve as frameworks for anti-viral strategies.•Alternatively, small molecules may upset crucial RdRp motions.

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