Configuration and validation of an analytical model predicting secondary neutron radiation in proton therapy using Monte Carlo simulations and experimental measurements

•Developing an MC-based analytical model reproducing stray neutrons in proton therapy.•Upgrading the literature model to enable full 3D H*(10) neutron mapping.•Limited efficiency of the literature model in a clinically-relevant configuration.•Upgrades given to model neutron variation with beam collimation and modulation.•MC-based analytical model consolidated with experimental measurements.