Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.

Arif U Hasan,Koji Ohmori,Kumi Konishi,Junsuke Igarashi,Takeshi Hashimoto,Kazuyo Kamitori,Fuminori Yamaguchi,Ikuko Tsukamoto,Toru Uyama,Yasuhiro Ishihara,Takahisa Noma,Masaaki Tokuda,Masakazu Kohno

Molecular and Cellular Endocrinology（2015）

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摘要

•EPA upregulated VEGF-A production in mature 3T3-L1 adipocytes.•GPR120 silencing or chemical inhibition of PPARγ attenuated the effect on VEGF-A.•GPR120 and PPARγ genes synergistically enhanced VEGF-A transcription in HEK293 cells.•GPR120 augmented PPARγ binding to PPRE in VEGF-A promoter region.•EPA links membrane receptor GRP120 and nuclear receptor PPARγ for VEGF-A production.

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关键词

ω-3 fatty acids,G proteins,Protein kinases/MAP kinase,Cytokines,Obesity,Diabetes

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