A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents Brian Finan , Bin Yang , Nickki Ottaway , David L Smiley , Tao Ma , Christoffer Clemmensen , Joe Chabenne , Lianshan Zhang , Kirk M Habegger , Katrin Fischer , Jonathan E Campbell , Darleen Sandoval , Randy J Seeley , Konrad Bleicher , Sabine Uhles , William Riboulet , Jürgen Funk , Cornelia Hertel , Sara Belli , Elena Sebokova , Karin Conde-Knape , Anish Konkar , Daniel J Drucker , Vasily Gelfanov , Paul T Pfluger , Timo D Müller , Diego Perez-Tilve , Richard D DiMarchi , Matthias H Tschöp NATURE MEDICINE(2014)
摘要
rationally designed peptide agonist that targets three key hormone receptors reduces obesity and its complications in a manner superior to other agonists.
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nature medicine, science
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