Correlation between FLT3–ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias

Carolina Pereira Souza Melo,Catharina Brant Campos,Álvaro Pimenta Dutra,Joaquim Caetano Aguirre Neto, Alexandre José Silva Fenelon,Abrahão Hallack Neto,Edna Kakitani Carbone,Mara Albonei Dudeque Pianovski,Alessandro Clayton de Souza Ferreira,Juliana Godoy Assumpcão

Leukemia Research（2015）

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摘要

•Acute promyelocytic patients carrying FLT3–ITD mutations have distinct biological features.•FLT3–ITD mutation is associated with higher Hb and WBC levels, bcr3 isoform, CD34 and CD2 expression.•Hb>9.6g/dL and WBC≥20×109/L were important factors for predicting ITD presence.•We report genes that are differentially expressed between FLT3–ITD carries and non-carriers.

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关键词

Acute promyelocytic leukemia,t(15,17),FLT3–ITD,PML–RARA,AML M3

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