VLSI multivariate phase synchronization epileptic seizure detector

A low-power VLSI seizure detector is presented. It combines a 256-channel analog neural recording chip and a low-power synthesized digital VLSI processor. The processor computes the bivariate phase synchronization on any two neural inputs from a set of 256 and their instantaneous magnitude. For experimentation with in vitro epilepsy models, a low-cost technique to implement on-chip gold microelectrodes was utilized. Results are shown using an in vitro low Mg2+ mouse epilepsy model and human EEG data.