FcεRIα Gene (FCER1A) Promoter Polymorphisms and Total Serum IgE Levels in Japanese Atopic Dermatitis Patients
INTERNATIONAL JOURNAL OF IMMUNOGENETICS(2010)
摘要
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
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