Validation of a quantitative FFQ for the Barbados National Cancer Study.

Objective: To assess the validity of a 148-item quantitative FFQ (QFFQ) that was developed for the Barbados National Cancer Study (BNCS) to determine dietary intake over 12 months and examine the dietary risk factors. Design: A cross-sectional validation study of the QFFQ against 4 d food diaries. Spearman's rank correlations (p), intra-class correlation coefficients (ICC) and weighted kappa were computed as measures of concordance, adjusting for daily variations in the food diaries. Cross-classification tables and Bland Altman plots were created for further assessment. Setting: BNCS is a case control study of environmental risk factors for breast and prostate cancer in a predominantly African-origin population in Barbados. Subjects: Fifty-four individuals (21 years and older) were recruited among controls in the BNCS who were frequency-matched on sex and age group to breast and prostate cancer cases. Results: Similar mean daily energy intake was derived from the food diary (8201 kJ (1960 kcal)) and QFFQ (7774 kJ (1858 kcal)). Rho for energy and macronutrients ranged from 0.66 (energy) to 0.17 (dietary fibre). The percentage of energy from carbohydrates and protein showed the highest and lowest ICC among macronutrients (0.63 and 0.27, respectively). The highest weighted kappa was observed for energy (0.45). When the nutrient intake was divided into quartiles, approximately 34% of the observations were in the same quartile. Conclusions: This investigation supports the validity of the QFFQ as a method for assessing long-term dietary intake except for dietary fibre, folate, vitamins A, E and B-12. The instrument will be a useful tool in the analysis of diet cancer associations in the BNCS.