Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

Eloïse Dray,Julia Etchin,Claudia Wiese,Dorina Saro,Gareth J Williams,Michal Hammel,Xiong Yu,Vitold E Galkin,Dongqing Liu,Miaw-Sheue Tsai,Shirley M-H Sy,David Schild,Edward Egelman,Junjie Chen,Patrick Sung

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2010）

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摘要

Tumor suppressor PALB2 is known to interact with BRCA1 and BRCA2, and to be required for the latter's localization to sites of DNA damage. Now PALB2 is shown to bind directly to DNA, to recombinase RAD51 and its accessory factor RAD51AP1. PALB2 also stimulates D loop formation by RAD51 in a synergistic manner with RAD51AP1.

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nature structural and molecular biology, science

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