Signaling diversity of PKA achieved via a Ca 2+ -cAMP-PKA oscillatory circuit

Qiang Ni,Ambhighainath Ganesan,Nwe-Nwe Aye-Han,Xinxin Gao,Michael D Allen,Andre Levchenko,Jin Zhang

Nature chemical biology（2010）

引用 105|浏览8

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摘要

PKA initiates and modulates the frequency of oscillations of Ca 2+ and cAMP in insulin-secreting cells and itself oscillates to provide spatiotemporal control of downstream signals on the basis of diverse inputs.

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nature chemical biology, science

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