Structural basis for RNA trimming by RNase T in stable RNA 3′-end maturation

Yu-Yuan Hsiao,Che-Chuan Yang,Chia Liang Lin,Jason L J Lin,Yulander Duh,Hanna S Yuan

Nature chemical biology（2011）

引用 31|浏览6

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摘要

RNase T is a 3′-to-5′ exonuclease involved in RNA maturation pathways. Biochemical and three-dimensional structures of RNase T in complex with single- or double-stranded DNA reveal mechanisms of substrate selection and catalysis by this nuclease.

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关键词

Enzyme mechanisms,RNA modification,Structural biology,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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