1-(Azolyl)-4-(aryl)-phthalazines: novel potent inhibitors of VEGF receptors I and II.
CHEMICAL BIOLOGY & DRUG DESIGN(2006)
摘要
Novel potent derivatives of phthalazine are described as an adenosine triphosphate-competitive inhibitors of vascular endothelial growth factor receptors I and II. A number of compounds display vascular endothelial growth factor receptor II inhibitory activity reaching that of Vatalanib (TM) A (IC50: < 50 nM) in an homogenous time-resolved fluorescence enzymatic assay.
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关键词
angiogenesis,adenosine triphosphate-competitive kinase inhibitors,phthalazines,vascular endothelial growth factor receptor II
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