Karotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells.

To the Editor: Although induced pluripotent stem cells (iPSCs) resemble embryonic stem cells (ESCs) with regard to pluripotency1, 2, reports of transcriptional, epigenetic and genetic differences between the two cell types emphasize the need for large-scale comparative analyses. We have performed karyotype analysis on >1,700 human iPSC and ESC cultures collected… Download references