Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2011)
摘要
We compared the abilities of structurally related cationic cyclodextrins to inhibit Bacillus anthracis lethal toxin and Staphylococcus aureus alpha-hemolysin. We found that both beta- and gamma-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores formed by the protective antigen (PA) subunit of the toxin, whereas alpha-cyclodextrins were ineffective. In contrast, alpha-hemolysin was selectively blocked only by beta-cyclodextrin derivatives, demonstrating that both symmetry and size of the inhibitor and the pore are important.
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关键词
bacterial toxins,cell death,cell line
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