Diagnostic-Significance Of Liver-Failure After Newly-Appeared Serum Fractions Following Liver Surgery

We investigated a serum marker suggesting postoperative liver failure based on basic research. In diseased Long Evans Cinnamon rat with spontaneous development of hepatitis and hepatocellular carcinoma, the specific fractions, Fr 43 (peak-1) and Fr 58-60 (peak-2), newly appeared in the eluted serum following highperformance liquid chromatography. Peak-1 was associated with progressing Liver damage or failure. We applied this theory to five patients undergoing liver surgery and our expectations were realized. Peak-1 was probably a certain hepatic regenerating factor recognized in a previous study and we suspected that the exessive production of a liver regenerating factor signified an ongoing liver failure.