Patterning small-molecule biocapture surfaces: microcontact insertion printing vs. photolithography (vol 47, pg 10641, 2011)

Chemical patterns prepared by self-assembly, combined with soft lithography or photolithography, are directly compared. Pattern fidelity can be controlled in both cases but patterning at the low densities necessary for small-molecule probe capture of large biomolecule targets is better accomplished using microcontact insertion printing (mu CIP). Surfaces patterned by mu CIP are used to capture biomolecule binding partners for the small molecules dopamine and biotin.