Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION(2011)
摘要
We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 +/- 3 vs. 179 +/- 3 mmHg, p < 0.05), reduced proteinuria (605.5 +/- 29.6 vs. 479.7 +/- 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.
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关键词
mineralocorticoid receptor antagonist,hypertension,end organ protection,eplerenone,Dahl salt-sensitive rats
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