Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Michael Reuter,Philipp Berninger,Shinichiro Chuma,Hardik Shah,Mihoko Hosokawa,Charlotta Funaya, Claude Antony,Ravi Sachidanandam,Ramesh S. Pillai

NATURE（2011）

引用 434|浏览2

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摘要

Piwi protein Miwi is shown to be a small RNA-guided RNase in mice; disrupting the catalytic activity of Miwi results in increased accumulation of LINE1 retrotransposon transcripts and male infertility.

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Biochemistry, Molecular biology

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