Evolving Strategies For Renoprotection: Non-Diabetic Chronic Renal Disease

Experimental and clinical studies over the past two decades have identified several interventions for slowing the progression of chronic renal disease towards end-stage renal failure. In this paper we review the experimental and clinical evidence in support of dietary protein restriction, angiotensin-converting enzyme inhibitor therapy, control of systemic hypertension, reduction of proteinuria, treatment of hyperlipidemia and smoking cessation. We also consider potential future renoprotective therapies, Finally we propose a comprehensive strategy for achieving maximal renoprotection with available interventions and monitoring. Curr Opin Nephrol Hypertens 10:523-531. (C) 2001 Lippincott Williams & Wilkins.