Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.

A Chris Krueger,Darold L Madigan,David W Beno,David A Betebenner,Robert Carrick,Brian E Green,Wenping He,Dachun Liu,Clarence J Maring,Keith F McDaniel,Hongmei Mo,Akhteruzzaman Molla,Christopher E Motter,Tami J Pilot-Matias,Michael D Tufano,Dale J Kempf

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.

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关键词

Hepatitis C,Replicon inhibitors,Pyrido[2,3-d]pyrimidines,Pyrimido[4,5-d]pyrimidines

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