Synthesis of Simplified Tedanolide Analogues—Connecting Tedanolide to Myriaporone and Gephyronic Acid
ChemMedChem(2012)
摘要
Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and evaluated for potency in mammalian cancer cells. The truncated analogues were found to retain significant activity in vitro (23 μmol mL(-1) for the example shown) compared with the parent compound tedanolide (0.33 nmol mL(-1)), and represent potential leads for the development of novel anticancer agents.
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关键词
gephyronic acid,myriaporones,natural products,ribosomes,tedanolide
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