Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

A series of thienopyridine ureas with dual inhibitory activity against KDR and Aurora B kinase has been identified. Compound 2 (ABT-348) of this series is currently undergoing Phase I clinical trials in solid and hematological cancer populations.

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关键词

Aurora kinase inhibitors,KDR kinase inhibitors,Thienopyridine ureas,Pyrazoles,Antitumor activity,ABT-348

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