Clinical study on zhenjian granule in improving essential hypertension and insulin resistance

Objective : To observe the effect of Zhenjian Granule (ZJG) in improving essential hypertension and insulin resistance (IR). Methods : The 52 patients of hypertension were randomly divided into the ZJG group (n=32) and the control group (n=20), treated with ZJG and captopril respectively for 4 weeks. The changes of blood pressure, glucose, insulin, insulin sensitivity index (ISI) and blood lipid in them before and after treatment were determined and compared with those in normal group (17 healthy subjects). Results : Fasting insulin, blood glucose, and insulin 2 hrs after meal in hypertension patients before treatment were significantly higher but ISI was significantly lower than those in the normal control, indicating the existence of insulin resistance. After treatment, not only blood pressure in patients obviously lowered, but also levels of fasting insulin, blood glucose, and insulin 2 hrs after meal obviously lowered, while ISI markedly raised. IR was improved in both groups, and blood lipid were also improved in the ZJG group. Conclusion : ZJG was effective in reducing blood pressure, also it had significant effect in improving metabolic disorder, particularly on IR in patients of essential hypertension.