Predictive Value of ABCB1 Polymorphisms G2677T/A, C3435T, and Their Haplotype in Small Cell Lung Cancer Patients Treated with Chemotherapy

L. Knez,M. Košnik, T. Ovčariček,A. Sadikov, E. Sodja,I. Kern,T. Cufer

Journal of cancer research and clinical oncology（2012）

引用 7|浏览4

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摘要

Multiple drug resistance limits the efficacy of numerous cytotoxic drugs used in the treatment of small cell lung cancer (SCLC). The drug efflux protein ATP-binding cassette transporter B1 (ABCB1) has an important role in this process, and its gene variability may affect chemotherapy outcomes.

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关键词

ABCB1 protein,Chemotherapy,Genetic polymorphisms,Multiple drug resistance,Small cell lung cancer

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