Rendering protein-based particles transiently insoluble for therapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2012)
摘要
Herein, we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.
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关键词
particle size,drug carriers,vero cells,cytoplasm,microtechnology,solubility,nanotechnology,rna
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