Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses

Hideo Negishi,Hideyuki Yanai,Akira Nakajima,Ryuji Koshiba,Koji Atarashi,Atsushi Matsuda,Kosuke Matsuki,Shoji Miki,Takahiro Doi,Alan Aderem,Junko Nishio,Stephen T Smale,Kenya Honda,Tadatsugu Taniguchi

NATURE IMMUNOLOGY（2012）

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摘要

Whether cross-interference between innate immune receptors affects the outcome of immune responses remains unclear. Taniguchi and colleagues show that RLR activation interferes with activation of the Il12b promoter induced by TLR signaling.

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nature immunology, science

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