Automated Parallel Solid-Phase Synthesis Of Non-Peptide Ccr1 Receptor Antagonists

Brad O Buckman,Ameen Ghannam,Li Angela,Meina Liang,Raju Mohan,Howard P Ng

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING（2002）

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摘要

An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCRI antagonists (K-i < 100 nM).

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