Antimicrobial activities of jadomycin B and structurally related analogues.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2009)
摘要
Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.
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关键词
amino acid,enzyme,molecular structure,structural complexity,genetics
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