Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus.

Magdalena M van der Kooi-Pol,Ewoud Reilman,Mark J J B Sibbald,Yanka K Veenstra-Kyuchukova,Thijs R H M Kouwen,Girbe Buist,Jan Maarten van Dijl

APPLIED AND ENVIRONMENTAL MICROBIOLOGY（2012）

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摘要

Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.

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gene expression,membrane proteins

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