Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.

Bioorganic & Medicinal Chemistry（2012）

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摘要

A library of 1,4-benzodiazepines and quinazoline-2,4-diones has been synthesised that display MIC values as low as 0.97μM against Trypanosoma brucei.

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关键词

Trypanosomiasis,Benzodiazepines

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