Clear-cut observation of PNA invasion using nanomechanical DNA origami devices.

Takahiro Yamazaki,Yuichiro Aiba,Kohei Yasuda,Yusuke Sakai,Yusei Yamanaka,Akinori Kuzuya,Yuichi Ohya,Makoto Komiyama

CHEMICAL COMMUNICATIONS（2012）

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摘要

Invasive binding event of PNA into DNA duplex was clearly observed both by atomic force microscope (AFM) imaging and electrophoretic mobility shift assay (EMSA) with the aid of nanomechanical DNA origami devices as 'single-molecule' visual probes, showing their potential as universal platform for the analysis of PNA invasion.

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