Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

Daniel M Andrews,Lucy C Sullivan,Nikola Baschuk,Christopher J Chan,Richard Berry, Claire L Cotterell,Jie Lin,Heloise Halse,Sally V Watt,Jennifer Poursine-Laurent,Chyung-Ru Wang,Anthony A Scalzo,Wayne M Yokoyama,Jamie Rossjohn,Andrew G Brooks,Mark J Smyth

NATURE IMMUNOLOGY（2012）

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摘要

NK cell licensing is governed by the interaction of Ly49 receptors with peptide-MHC complexes. Smyth and colleagues show that the nonclassical MHC class I molecule H2-M3 can also license NK cell functional development.

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关键词

MHC class I,NK cells,Biomedicine,general,Immunology,Infectious Diseases

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