Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis.

Samuele Tardito,Simone Negrini,Giuseppina Conteduca,Francesca Ferrera,Alessia Parodi,Florinda Battaglia,Francesca Kalli,Daniela Fenoglio,Maurizio Cutolo,Gilberto Filaci

Human Immunology（2013）

引用 25|浏览6

暂无评分

摘要

Systemic sclerosis (SSc) is characterized by tissue fibrosis, vasculopathy and autoimmunity. Indoleamine 2,3 dioxygenase (IDO) plays a pivotal role in immunological tolerance modulating regulatory T cell (Treg) generation and function. Single nucleotide polymorphisms (SNPs) of IDO gene could impact on Treg function and predispose to autoimmunity. Here, the existence of an association between specific IDO SNPs and SSc was analyzed.

查看译文

关键词

ido

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要