Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Mitsunori Kono,Takahiro Matsumoto,Toru Kawamura,Atsushi Nishimura,Yoshihiro Kiyota,Hideyuki Oki,Junichi Miyazaki,Shigeru Igaki,Craig A Behnke,Masato Shimojo,Masakuni Kori

Bioorganic & Medicinal Chemistry（2013）

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摘要

A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain.

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关键词

FAAH,EC,AEA,CB1,CB2,SAR,DMPK,Troc

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