Structure of the Proton-Gated Urea Channel from the Gastric Pathogen Helicobacter Pylori.

David Strugatsky,Reginald McNulty,Keith Munson,Chiung-Kuang Chen,S. Michael Soltis,George Sachs,Hartmut Luecke

Nature（2012）

引用 77|浏览9

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摘要

The crystal structure of the inner-membrane urea channel Hp UreI from Helicobacter pylori , the causative organism of peptic ulcers, reveals how the channel selectively transports urea across the membrane and buffers the pathogen’s periplasmic pH against the acidic gastric environment.

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关键词

Bacterial infection,Biochemistry,Biophysics,Ion channels,Pathogens,Physiology,Structural biology,Target validation,Science,Humanities and Social Sciences,multidisciplinary

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