Administration of the optimized β-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model.

The composition of a ternary system including the antitumoral β-Lapachone, random methylated- β-cyclodextrin and poloxamer 407 was optimized by using artificial intelligence tools. The optimal formulation it is syringeable at room temperature and forms a time-released depot of a high dose of β-Lapachone. Results showed that the administration of this complex induces apoptosis, DNA damage, and decreased tumor volume in mouse xenograft tumor mode.