Usefulness Of F-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography In Management Of Cervical Dystonia

Objective To evaluate the usefulness of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) in the management of cervical dystonia (CD) with botulinum toxin type A (BoNT-A) injection.Method Thirty two subjects with CD were included. A BoNT-A injection was provided either by clinically targeting method (group 1) or by F-18-FDG PET/CT-assisted, clinically targeting method (group 2). In group 2, selection of target muscles and dosage of BoNT-A were determined according to the increased F-18-FDG uptake, in addition to physical examination and functional anatomy. The outcomes of BoNT-A injection was compared between the two groups, in terms of the number of subjects who had reinjection before and after 6 months, the number of reinjections, the interval of reinjections, the duration to the minimal Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), the number of adverse events, the reduction rate of TWSTRS at 1-3 months and 3-6 months after injection, and the probability of reinjection-free living.Results The number of subjects who had reinjection within 6 months was significantly lower in group 2 than in group 1 (10 in group 1 vs. 3 in group 2). The reduction rate of TWSTRS after 3-6 months (37.8 +/- 15.7% of group 1 vs. 63.3 +/- 28.0% of group 2) and the probability of reinjection-free living were significantly higher in group 2 than in group 1.Conclusion These findings suggest that F-18-FDG PET/CT study could be useful in management of CD in terms of the identification of dystonic muscles if there is an increase in the F-18-FDG uptake in the cervical muscle of the images.