Inhibition of TGF-beta receptor I by siRNA suppresses the motility and invasiveness of T24 bladder cancer cells via modulation of integrins and matrix metalloproteinase.
International urology and nephrology（2010）
摘要
Our study suggested that inhibition of TGF-beta1 signaling pathway by siRNA could be beneficial in the treatment of patients with metastatic bladder cancer.
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关键词
Bladder cancer,Transforming growth factor-beta 1 (TGF-beta 1),TGF-beta type I receptor (TGFBRI),RNA interference (RNAi),Invasion/cell motility
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