Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients.

Maria Alice V Willrich,Alice C Rodrigues,Alvaro Cerda,Fabiana D V Genvigir,Simone S Arazi,Egidio L Dorea,Marcia M S Bernik,Marcelo C Bertolami,Andre Faludi,Alvaro Largura,Linnea M Baudhuin,Sandra C Bryant,Mario Hiroyuki Hirata,Rosario Dominguez Crespo Hirata

Clinica Chimica Acta（2013）

引用 22|浏览6

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摘要

•Atorvastatin impact on CYP3A activity, mRNA expression and variants was evaluated.•LDL reduction after atorvastatin was correlated with CYP3A4/5 change in mRNA levels.•AGT haplotype was associated with lower basal levels of CYP3A5 mRNA expression.

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关键词

Pharmacogenomics,Atorvastatin,CYP3A4,CYP3A5,mRNA expression,CYP3A activity

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