Towards a Biocompatible Artificial Lung: Covalent Functionalization of Poly(4-Methylpent-1-ene) (TPX) with Crgd Pentapeptide

Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.