Neutralization of alpha(2)-antiplasmin by microplasmin: a randomized, double-blind, placebo-controlled, ascending-dose study in healthy male volunteers.
Clinical Therapeutics（2009）
摘要
Background: Microplasmin is the isolated proteinase domain of plasmin. Administration of microplasmin has been found to neutralize α2-antiplasmin (α2-AP) activity, which has been associated with reduced infarct size in various preclinical models of stroke.
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关键词
microplasmin,plasmin,α2-antiplasmin,fibrinolysis,tissue-plasminogen activator,stroke,neuroprotection
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